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PHOTODYNAMIC THERAPY ENABLED DNA-FORK-BINDING METALLO-CYLINDERS: DRUGS AND RELEASE TRIGGERS

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PHOTOCYLINDER

project was aimed to accomplish two principal objectives: (1) Synthesis of novel Photo cylinders (2) Evaluation of the efficiency of the photo cylinder to bind to DNA 3-way junction and their photodynamic potential in cancer cells.  The first objective of this research has been successfully achieved and two new photo cylinders were synthesized and characterized. With the newly designed photo cylinders we then evaluated the ability of the photo cylinders to bind DNA 3-way junctions. We found that these initial photocylinders did not efficiently bind DNA 3-way Junctions due to the connectivity of the units.   To achieve the second objective of the project we established a new collaboration with Prof. Palin at the School of Dentistry, University of Birmingham. We studied the photocytotoxicity and cellular localization and uptake of the cylinders in Sarcoma osteogenic -2 cell lines.

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Dissemination of the results

I have published two papers as a co-author in JACS (J. Am. Chem. Soc., 2020, 142, 20651-20660) and Angew Chem (Angew Chem Int Ed Engl. 2021, 60, 18144-1815.) in collaboration with post-graduate students from the host group. We anticipate at least 1 additional paper will result.

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Harvard Medical School

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